Modular organization of cellular networks
نویسندگان
چکیده
منابع مشابه
Modular organization of cellular networks.
We investigated the organization of interacting proteins and protein complexes into networks of modules. A network-clustering method was developed to identify modules. This method of network-structure determination was validated by clustering known signaling-protein modules and by identifying module rudiments in exclusively high-throughput protein-interaction data with high error frequencies an...
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We examine the global organization of heterogeneous equilibrium networks consisting of a number of well-distinguished interconnected parts-"communities" or modules. We develop an analytical approach allowing us to obtain the statistics of connected components and the intervertex distance distribution in these modular networks, and to describe their global organization and structure. In particul...
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Brain networks are increasingly understood as one of a large class of information processing systems that share important organizational principles in common, including the property of a modular community structure. A module is topologically defined as a subset of highly inter-connected nodes which are relatively sparsely connected to nodes in other modules. In brain networks, topological modul...
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MOTIVATION Accumulating evidence suggests that biological systems are composed of interacting, separable, functional modules. Identifying these modules is essential to understand the organization of biological systems. RESULT In this paper, we present a framework to identify modules within biological networks. In this approach, the concept of degree is extended from the single vertex to the s...
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Impulsivity is a complex trait associated with a range of maladaptive behaviors, including many forms of psychopathology. Previous research has implicated multiple neural circuits and neurotransmitter systems in impulsive behavior, but the relationship between impulsivity and organization of whole-brain networks has not yet been explored. Using graph theory analyses, we characterized the relati...
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ژورنال
عنوان ژورنال: Proceedings of the National Academy of Sciences
سال: 2003
ISSN: 0027-8424,1091-6490
DOI: 10.1073/pnas.0237338100